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Key research papers:

  • Lettieri A, Oleari R, van den Munkhof MH, van Battum EY, Verhagen MG, Tacconi C, Spreafico M, Paganoni AJJ, Azzarelli R, Andre’ V, Amoruso F, Palazzolo L, Eberini I, Dunkel L, Howard SR, Fantin A, Pasterkamp RJ, Cariboni A. SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nature Comm. 2023 Dec.
  • Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y, Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H, Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N, Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R, Moeendarbary E. Emergent mechanical control of vascular morphogenesis. Sci Adv. 2023 Aug 11;9(32):eadg9781.
  • Ceccacci E, Villa E, Santoro F, Minucci S, Ruhrberg C, Fantin A. A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver. J. Dev. Biol. 2023, 11(2), 15.
  • Tacconi C, Plein A, Colletto C, Villa E, Denti L, Barone C, Javanmardi Y, Moeendarbary E, Azzoni E, Fantin A, Ruhrberg C. KIT is dispensable for physiological organ vascularisation in the embryo. Angiogenesis. 2022 Apr 13. doi: 10.1007/s10456-022-09837-6.
  • Fantin A, Tacconi C, Villa E, Ceccacci E, Denti L, Ruhrberg C. KIT Is Required for Fetal Liver Hematopoiesis. Front Cell Dev Biol. 2021 Jul 29;9:648630. doi: 10.3389/fcell.2021.648630.
  • Oleari R, Caramello A, Campinoti S, Lettieri A, Ioannou E, Paganoni A, Fantin A, Cariboni A, Ruhrberg C. PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons. Development. 2019 Nov 5;146(21).
  • Plein A, Fantin A, Denti L, Pollard JW, Ruhrberg C. Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018 Oct;562(7726):223-228.
  • Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange C, Liyanage SE, Raimondi C, Bainbridge J, Augustin HG, Ruhrberg C. VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. J Exp Med. 2017 Apr 3;214(4):1049-1064.
  • Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BV, Brennan CH, Maffucci T, Larijani B, Falasca M. A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Sci Rep. 2016 May 20;6:26142.
  • Liyanage SE, Fantin A, Villacampa P, Lange CA, Denti L, Cristante E, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW, Ruhrberg C. Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization. ATVB. 2016 Jan;36(1):19-24.
  • Fantin A, Vieira JM, Plein A, Denti L, Fruttiger M, Pollard J, Ruhrberg C. NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood. 2013 Mar;121(12):2352-62. 
  • Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S, Peri F, Wilson SW, Ruhrberg C. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. 2010 Aug;116(5):829-40.
Key review/protocol papers:

  • Brash JT, Ruhrberg C, Fantin A. Evaluating VEGF-Induced Vascular Leakage Using the Miles Assay. Methods Mol Biol. 2022;2475:289-295. doi: 10.1007/978-1-0716-2217-9_21.
  • Fantin A, Ruhrberg C. The embryonic mouse hindbrain and postnatal retina as in vivo models to study angiogenesis. VEGF Signalling: Methods and Protocols (book chapter). Methods Mol Biol. 2022;2475:275-287. doi: 10.1007/978-1-0716-2217-9_20.
  • Domingues A, Fantin A. Neuropilin 1 Regulation of Vascular Permeability Signaling. Biomolecules. 2021 Apr 29;11(5):666. doi: 10.3390/biom11050666.
  • Brash JT, Ruhrberg C, Fantin A. Evaluating Vascular Hyperpermeability-Inducing Agents in the Skin with the Miles Assay. J Vis Exp. 2018 Jun 19;(136). doi: 10.3791/57524.
  • Tata M, Ruhrberg C, Fantin A. Vascularisation of the central nervous system. Mech Dev. 2015 Nov;138 Pt 1:26-36.
  • Fantin A, Vieira JM, Plein A, Maden CH, Ruhrberg C. The embryonic mouse hindbrain as a qualitative and quantitative model to study the molecular and cellular mechanisms of angiogenesis. Nature Protocols. 2013 Jan;8(2):418-429.